Middle School. The threshold to puberty, and the beginning of the end of childhood innocence. Shuichi Nitori and his new friend Yoshino Takatsuki have happy homes, loving families, and are well liked by their classmates. But they share a secret that further complicates a time of life that is awkward for anyone: Shuichi is a boy who wants to be a girl, and Yoshino is a girl who wants to be a boy.